Sunday, May 18, 2008: 1:30 PM-5:00 PM
Science Building, Rm S-111 (Queensborough Community College)
Medicinal Chemistry
Sponsor: ACS Division of Medicinal Chemistry
Organizers:Ralph A. Stephani
Tanaji Talele
Vijaya Korlipara
1:30 PM56Protein-Protein Interactions: Drugability, Design Strategies in Lead Identification and Optimization
Hariprasad Vankayalapati
2:15 PM57Evolution of Selective IGF1R Inhibitors
Kenneth W. Foreman
3:00 PM58Discovery of the Multi- Kinase Inhibitor Dasatinib (SPRYCEL�) for the Treatment of Philadelphia Chromosome Positive Leukemias
Jagabandhu Das, Francis Y, Lee, Ping Chen, Derek Norris, Kamelia Behnia, Amy Camuso, Stephen Castaneda, Lyndon A. M. Cornelius, Arthur M. Doweyko, Krista Fager, Christine Flefleh, Craig Fairchild, John T. Hunt, Ivan Inigo, Kathy Johnston, Amrita Kamath, David Kan, Herbert Klei, Roger Luo, Punit Marathe, Suhong Pang, Russell Peterson, Sidney Pitt, Gary L. Schieven, Robert J. Schmidt, John Tokarski, Mei-Li Wen, Robert Wild, Joh Wityak, Louis J. Lombardo, Robert M. Borzilleri, Joel C. Barrish
3:45 PM Break
4:00 PM59Fragment Based Design of p53/MDM2/MDM4 Inhibitors Utilizing Multi Component Reaction (MCR) Chemistry
Barbara Beck, Stuti Srivastava, Balachandran Raghavan, Alexander Doemling, Tad Holak
4:30 PM60Potent XIAP Antagonists by a Fragment-Based MCR Approach
Ilaria Monfardini, Alexander Doemling, Maurizio Pellecchia

Back to The 40th Middle Atlantic Regional Meeting (MARM) (May 17�21, 2008)