During the past three decades, the bond formations (C-C, C-X)  promoted  by transition  metals  are  extensively  studied,  and  widely  applied  in  the organic syntheses as the most successful,  and reliable methods. In general, this transformation includes three elementary reactions: (1) oxidative addition, (2) Transmetallation, (3) Reductive Elimination.  Herein, we would like  to introduce a new approach: the oxidative cross-coupling, which involves double transmetallation, ^1-3 and reductive elimination (Scheme 1).       Using desyl chloride as the oxidant, a Csp-Sn reagent and a Csp3-Zn reagent can couple together with surprisingly high selectivity.⁴ When the Csp3-Zn reagents have b-H, the coupling can take place well in high yield as well as the selectivity. The coupling of Csp-Sn and Csp2-Zn was also examined, and high yield of the desired cross-coupling products were obtained. Our kinetic data from ReactorIR, ¹³C NMR indicate that the organozinc reagents are highly oxophilic, and the organotin reagent might be halophilic.