Sunday, May 18, 2008 - 3:00 PM
Science Building, Rm S-112 (Queensborough Community College)
64

Development of a Scaleable Process for Product Quality Improvement Using Adsorbents

Melodie D. McCain, Jungchul Kim, Jennifer Vance, and Thomas Hunter. Schering-Plough, Union, NJ

Adsorbent materials have been widely used in pharmaceutical process development in order remove low-level impurities such as residual metals, colored impurities and organic impurities. Current adsorbent technologies include adsorbent screening kits and adsorbent cartridges.

Two case studies will be presented. The first case will describe the development of a process to remove residual Pd from a pharmaceutical product utilizing adsorbent kit screening. The second case will describe the rapid development of a process to remove blue color from a pharmaceutical intermediate.