As part of an initiative to develop a biosensor for the detection of ovarian cancer using nanowire arrays, gold and silver nanowires are cleaned and roughened using electrochemical techniques and functionalized with a self-assembled monolayer. Cleaning of the wire arrays removes impurities from the array surface to facilitate functionalization, while roughening increases the analytical signal obtained. The gold and silver arrays will be run at several voltages to determine their respective optimal voltages and characterized using scanning electron microscopy. The gold and silver arrays are then functionalized with a self-assembled monolayer consisting of mercaptoundecanoic acid and a spacer molecule, with the thiol group to bind to the nanowires, and again with cancer antibodies. The acid of the monolayer acts a site to which antibodies can bind, while the spacer ensures that the antibodies have the space to correctly bind. Fluorescent microscopy will be used to determine the correct spacer molecule to use and the optimal ratio of spacer molecules to acid molecules to produce the largest amount of antibody attachment with the correct orientation.