Friday, 18 May 2007
3rd Floor Hall (Pfahler Hall)
472

New Methanopyrrolidines. Modification of 5(6)-Bromo Substituents in N-Benzyl-2-azabicyclo[2.1.1]hexanes

Ram Edupuganti, Deepa Rapolu, Guoliang Lin, Charles DeBrosse, and Grant R. Krow. Temple University, Philadelphia, PA

Abstract: Novel methanopyrrolidines have been prepared from pyridine. N–Benzyl-5-anti,6-anti-dibromo-2-azabicyclo[2.1.1]hexane (1) is a key synthon for the preparation of new mono- and di- F, OAc, OH, CN, SCN, NH2 with the help of neighboring group participation. Some unusual structural properties of these methanopyrrolidines will be presented.


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