Friday, 18 May 2007 - 8:30 AM
210 (Pfahler Hall)
407

Diastereoselective Addition of Organometallic Reagents to Chiral γ-Hydroxybutenolides

William H. Miles, Daniela G. Duca, Jayrd T. Freedman, Elliot O. Goodzeit, Kristin B. Hamman, Chiquita A. Palha De Sousa, Brandon R. Selfridge, and Pui-In Tang. Lafayette College, Easton, PA

The γ-hydroxybutenolide moiety is a readily accessible but underutilized functional group. We have developed conditions for the diastereoselective addition of a methyl group to chiral γ-hydroxybutenolides 1. The addition of other groups to 1 and related asymmetric synthetic studies of γ-hydroxybutenolides will be discussed.


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